fa26-philos244 philos244
Organoid Intelligence: The New Frontier in Biocomputing and Intelligence-in-a-Dish Organoid Intelligence: The New Frontier in Biocomputing and Intelligence-in-a-Dish
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Abstract
Key points
Introduction
Prerequisites for biocomputing models
Culture and bioengineering technologies to advance 3D brain organoids
Advances in 3D organoid culture
Microfluidic perfusion systems
High-resolution recording of complex neuronal networks
3D microelectrode arrays for brain organoids
High-resolution implantable electrophysiology devices
All-optical
High-throughput electrophysiology
Memory and learning in organoids: training using biofeedback, big data, and AI/machine learning
AI analysis of responses
Big-data infrastructures
Advancing biocomputing complexity
Optimized algorithms for organoid-in silico interactions
Incorporating complex biological inputs in OI
Leveraging advances in the molecular basis of biological learning
OI-led advances in medical research and innovation
Ethics of biological computing with organoids
Conclusion: an action plan for OI research
Data availability statement
Acknowledgments
Conflict of interest
References
Publisher’s note